| 角色 | 饰演者 | 角色介绍 |
| Neville | 威尔·史密斯 | |
| Anna | 艾莉丝·布拉加 | |
| Ginny Neville | 莎莉·理查德森 | |
| Alpha Guard | Paradox Pollack | |
| Ethan | 查理·塔汗 | |
| Marley | 薇洛·史密斯 | |
| Mike - Military Escort | Darrell Foster | |
| TV Personality | 艾普尔·格蕾丝 | |
| Alpha Female | Joanna Numata | |
| Military Driver - Jay | Samuel Glen | |
| Male Evacuee (as James McCauley) | James Michael McCauley | |
| Woman Evacuee | 玛琳·艾尔兰 | |
| Sergeant | Pedro Mojica | |
| Evacuation Cop (as Anthony Mazza) | Anthony C. Mazza | |
| Military Police | Steve Cirbus | |
| Little Girl Evacuee #1 | Calista Hill | |
| Little Girl Evacuee #2 | Gabriella Hill | |
| Little Girl Evacuee #3 | Madeline Hill | |
| Military Scanning Tech | Adhi Sharma | |
| Evacuation Cop #2 (as Tyree Simpson) | Tyree Michael Simpson | |
| Coast Guard Ground Crew | Blake Lange | |
| Male Evacuee #2 | Alexander DiPersia | |
| Male Evacuee #3 | Abraham Sparrow | |
| President (as Patrick Fraley) | Pat Fraley | |
| Special Blond Model | Caitlin McHugh | |
| Civilian | Deborah Collins | |
| Creature Vocals (voice) (as Michael A. Patton) | Mike Patton | |
| Infected | Katherine Brook | |
| Infected | Vince Capone | |
| Infected | Lynna' Davis | |
| Infected | Anika Ellis | |
| Infected | John Grady |
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