| 角色 | 饰演者 | 角色介绍 |
| Olivia Dunham? (100 episodes 2008-2013) | 安娜·托芙 | |
| Dr. Walter Bishop? (100 episodes 2008-2013) | 约翰·诺贝尔 | |
| Peter Bishop (100 episodes 2008-2013) | 乔舒亚·杰克逊 | |
| Astrid Farnsworth? (100 episodes 2008-2013) | 杰西卡·妮可 | |
| Phillip Broyles? (93 episodes 2008-2013) | 兰斯·莱迪克 | |
| Nina Sharp? (93 episodes 2008-2013) | 布莱尔·布朗 | |
| The Observer? (36 episodes 2008-2012) | Michael Cerveris | |
| Charlie Francis? (34 episodes 2008-2011) | 柯克·埃斯沃多 | |
| Lincoln Lee? (33 episodes 2010-2012) | 塞斯·盖贝尔 | |
| Brandon Fayette? (20 episodes 2009-2012) | 瑞安·麦克唐纳德 | |
| John Scott (12 episodes 2008-2009) | 马克·瓦雷 | |
| Ella (11 episodes 2009-2010) | Lily Pilblad | |
| Dr. William Bell? (11 episodes 2009-2012) | 伦纳德·尼莫伊 | |
| Captain Windmark (11 episodes 2012-2013) | Mike Kopsa | |
| Rachel? (10 episodes 2009-2010) | 阿丽·格雷勒 | |
| David Robert Jones (9 episodes 2008-2012) | 杰瑞德·哈里斯 | |
| Thomas Jerome Newton (8 episodes 2009-2010) | Sebastian Roché | |
| December (8 episodes 2009-2012) | Eugene Lipinski | |
| Sam Weiss (7 episodes 2009-2011) | 凯文·考利甘 | |
| Anil (7 episodes 2012-2013) | Shaun Smyth | |
| Agent Tim? (6 episodes 2010-2012) | Jarod Joseph |
