| 角色 | 饰演者 | 角色介绍 |
| Machete Cortez | 丹尼·特乔 | |
| Sartana Rivera | 杰西卡·阿尔芭  | |
| Senator John McLaughlin | 罗伯特·德尼罗 | |
| Torrez | 史蒂文·席格 | |
| Luz | 米歇尔·罗德里格兹 | |
| Michael Booth | 杰夫·法赫 | |
| Padre Cortez | 切奇·马林 | |
| Von Jackson | 唐·约翰逊 | |
| Sniper | 希亚·温汉 | |
| April Booth | 琳赛·洛翰 | |
| Julio | 达里尔·沙巴拉 | |
| Jorge | Gilbert Trejo | |
| Nurse Mona | 艾莱特拉·阿维兰 | |
| Osiris Amanpour | 汤姆·萨维尼 | |
| Von's Henchman | Billy Blair | |
| Doc Felix | Felix Sabates | |
| Reporter | Ara Celi | |
| Nurse Lisa | Elise Avellan | |
| Nurse Fine | Marci Madison | |
| Federale Officer | Vic Trevino | |
| Chica (Naked Girl) | Mayra Leal | |
| Chief | Alejandro Antonio | |
| Rico (as Juan Pareja) | Juan Gabriel Pareja | |
| June Booth (as Alicia Marek) | 阿利西亚·瑞秋·马瑞科 | |
| Patrolman #1 | 杰森·道格拉斯 | |
| Patrolman #2 | Mitchell Lance Adams | |
| Sniper's Henchman | Brent Smiga | |
| Hospital Security Guard | Chris Warner | |
| Guard | Jim Henry | |
| Tristana | 克里斯蒂娜·罗德里格兹 | |
| Luis | Roland Ruiz | |
| Cristos | 格莱格·英格拉姆 | |
| Culebra Cruzado | 迪图·拉里瓦 | |
| Torrez Henchwoman (as Cheryl 'Chin' Cunningham) | Cheryl Chin | |
| Driver (Van) | Hugo Perez | |
| Machete's Wife | Nina Leon | |
| Von's Minute Man | Doran Ingram | |
| Henchman | James Brownlee | |
| Booth's Bodyguard #1 | 尼莫洛德·安塔尔 | |
| Bodyguard #3 | Dimitrius Pulido |
