| Vash the Stampede | 小野坂昌也
 | |
| Milly Thompson | 雪野五月
 | |
| Nicholas D. Wolfwood | 速水奖
 | |
| Leonov the Puppetmaster | 肝付兼太
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| Rai-Dei the Blade | 大冢明夫
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| Kaite | 松本梨香
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| Brilliant Dynamites Neon | 石塚运升
 | |
| Rem Saverem (voice) | 布里奇特·霍夫曼
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| Meryl Stryfe | 鹤广美
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| Rem Saverem | 久川绫
 | |
| Millions Knives | 古泽彻
 | |
| Legato Bluesummers | 关俊彦
 | |
| Descartes | 乡里大辅
 | |
| Midvalley the Hornfreak | 西村朋纮
 | |
| Hoppered the Gauntlet | 难波圭一
 | |
| Zazie the Beast | 神谷浩史
 | |
| Chapel the Evergreen | 铃置洋孝
 | |
| Dominique the Cyclops | Y?ko Sawami | |
| Monev the Gale | 天田益男
 | |
| Loose Ruth | 岸野幸正
 | |
| E.G Mine | 堀川亮
 | |
| Meryl Strife (English dub) (voice: English version) (as Dorothy Melendrez) | Dorothy Melendrez | |
| Milly Thompson (English dub) (English version) | Lia Sargent | |
| Nicholas D. Wolfwood (English dub) (voice) | Bo Williams | |
| Millions Knives (voice: English version) | George C. Cole | |
| (voice: English version) | Ronya Abbott | |
| (voice) | Steve Areno | |
| (voice: English version) | Heather Ashton | |
| (voice: English version) | Michaline Babich | |
| (voice) | Milton James | |
| Additional Voices (voice: English version) | James Bates | |
| (voice) | Lauren Benjamin | |
