| 角色 | 饰演者介绍 |
| Meg Murry | Katie Stuart |
| Calvin O'Keefe | 格里高利·史密斯 |
| Charles Wallace Murry | 大卫·多夫曼 |
| Dr. Jack Murry | 克里斯·波特 |
| The Man With Red Eyes | Kyle Secor |
| Happy Medium | Sean Cullen |
| Dr. Dana Murry | Sarah-Jane Redmond |
| Mrs. Which | 凯特·尼利甘 |
| Mrs. Who | 艾丽森·艾略特 |
| Mrs. Whatsit | 阿尔法·沃德 |
| Sandy Murry | Munro Chambers |
| Dennys Murry | Thomas Chambers |
| Aunt Beast | Ellen Dubin |
| Bingo Man | Guy Fauchon |
| Eric O'Keefe | 亚历山大·波洛克 |
| Max | Bryce Hodgson |
| Louie | Matthew Brevner |
| Isabel | Rachel Victoria |
| Mr. Porter | Norman Armour |
| Mr. Jenkins | Roger Haskett |
| Ms. Myles | Angela Moore |
| Young Meg | Angelica Kero |
| Calvin's Mom (as Nancy Lilley) | Nancy J. Lilley |
| Billy | Jeff Ballard |
| Billy's Mom | Anita Adams |
| Valentina Tereshkova | Apollonia Vanova |
| 14 Year Old "IT" Girl | Alexa Fox |
| 16 Year Old "IT" Boy | Noel Fisher |
| 6 Year Old "IT" Girl | Jacoba Rozema |
| School Girl # 1 | Christine Kennedy |
| School Girl # 2 (as Sarah La Greca) | Sarah Le Greca |
| Camazotz Boy # 1 | Robbie Ruddell |
| Stone Face | Peter Benson |
| Camazotz Lady | Iris Quinn |
| Guard # 1 | Shawn Reis |
| Secretary | Sarah Hayward |
| Ubalon (uncredited) | 保罗·贝克尔 |
