| Cleveland Brown? (126 episodes 1999-2010) | Mike Henry | |
| Brian Griffin? (144 episodes 1999-2010) | 塞思·麦克法兰
 | |
| Lois Griffin? (143 episodes 1999-2010) | Alex Borstein
 | |
| Chris Griffin? (143 episodes 1999-2010) | 赛斯·格林
 | |
| Meg Griffin? (131 episodes 1999-2010) | 米拉·库妮丝
 | |
| Joe Swanson? (91 episodes 1999-2010) | 帕特里克·沃伯顿
 | |
| Diane Simmons? (59 episodes 1999-2010) | Lori Alan
 | |
| Various? (103 episodes 1999-2010) | Danny Smith | |
| Mayor Adam West? (51 episodes 2000-2010) | 亚当·威斯特
 | |
| Judge? (43 episodes 1999-2010) | 菲尔·拉马
 | |
| Various? (51 episodes 2001-2010) | 拉尔夫·戈曼
 | |
| Mike Brady? (26 episodes 2000-2009) | 盖瑞·科尔
 | |
| Muriel Goldman? (22 episodes 2000-2009) | Nicole Sullivan
 | |
| Bonnie Swanson (23 episodes 1999-2010) | 珍妮佛·提莉
 | |
| Mort Goldman? (41 episodes 2000-2010) | John G. Brennan | |
| Various? (21 episodes 1999-2009) | 弗莱德·塔他斯西奥
 | |
| Meg Griffin (15 episodes 1999-2000) | 莱西·沙伯特
 | |
| Bill Cosby? (14 episodes 1999-2009) | Kevin Michael Richardson
 | |
| Various? (33 episodes 1999-2009) | Wally Wingert | |
| Connie D'Amico? (14 episodes 2000-2010) | Lisa Wilhoit | |
