| 角色 | 饰演者 | 角色介绍 |
| 埃迪·布洛克/毒液 | 汤姆·哈迪 | |
| 安妮·韦英 | 米歇尔·威廉姆斯 | |
| 德雷克博士 | 里兹·阿迈德 | |
| Dr. Dora Skirth | 珍妮·斯蕾特 | |
| Dr. Dan Lewis | 瑞德·斯科特 | |
| Security Chief Roland Treece | 斯科特·黑兹 | |
| Cletus Kasady | 伍迪·哈里森 | |
| Donna Diego | 米歇尔·李 | |
| Shakedown Thug | 山姆·梅迪纳 | |
| Isaac | 杰瑞德·本肯斯 | |
| SFPD Officer | Van Marten | |
| Tater Tot Girl | Sailor Larocque | |
| Stoner Dude #2 | Al-Jaleel Knox | |
| Restaurant Patron | Laura Distin | |
| LF Security Guard | DJames Jones | |
| Chasing Guard | Otis Winston | |
| Actress | Grace Wan | |
| Orderly | Jock McKissic | |
| Villager | Apollo GT | |
| Scientist /Lab Tech | Daniela Gaskie | |
| Villager | Kayko Thompson | |
| Hazmat Crew | Paul Pillsbury | |
| Restaurant Patron | Jessica Dawson Str.. | |
| Pedestrian /Restaurant Patron | Anthony B. Harris | |
| Neighborhood Couple | Marcella Bragio | |
| Jack the Bartender | Mac Brandt | |
| Dr. Emerson | 韦恩·佩雷 | |
| Bistro Manager | Selena Anduze | |
| Joey-8 Year Old Boy | Christian Convery | |
| Street Pedestrian /Business Woman | Cassandra Hendry | |
| Driver /Street Pedestrian | Gail Gamble | |
| Restaurant Patron | Jane McNeill | |
| Waiter #2 | James Fuertes | |
| Mission Control Operator | Chris Stein | |
| Scientist /Lab Tech | Marquis Magwood | |
| Trolly Teen #1 | Boston Rush | |
| Window shopper | Etienne Vick | |
| Volunteer 1 | Martin Bats Bradford | |
| Mrs. Manfredi | Ellen Gerstein | |
| SF Pedestrian | Vaughn Myovich | |
| Restaurant Patron #2 | Elizabeth Becka | |
| Street Pedestrian | Homero Lopez | |
| Neighborhood Couple | William W. Barbour | |
| Producer | Ariadne Joseph | |
| Johnson Prison Guard | John Ozuna | |
| Sailor | Kevin Carscallen | |
| Prison Guard | Ronnie Yelverton | |
| Sailor | Carl Collanus | |
| SFPD Officer | John Lobato | |
| Cafe Patron | Mary Lu Marr | |
| Boys Mother | Tianna Hazard | |
| Tech Girl | Angelina | |
| San Francisco Tourist | Cabran E. Chamberl.. | |
| Pedestrian | Ed Moy | |
| Pedestrian with car | Jeff Redlick | |
| Window shopper | Amanda Marie Wilki.. | |
| Dr. Collins | Sope Aluko | |
| Noisy Neighbor Ziggy | Scotty Dickert | |
| Operations Specialist | Donald K. Overstreet | |
| Donna Diego /old woman | Vickie Eng | |
| Officer #1 | Brandon Morales | |
| Strip Club Patron | Jake Hanson | |
| S.W.A.T Leader | Phillip Marshall T.. | |
| Villager | Amy Le | |
| Merc Driver | Denney Pierce | |
| Swat Team #9 | Khalid Ghajji | |
| Scientist /Lab Tech | Carter Burch | |
| Mrs. Chen | Peggy Lu | |
| Pedestrian | James D. Weston II | |
| Villager | Emelita T. Gonzalez | |
| Street Pedestrian | Joseph Amey | |
| Bistro Chef | Ray Benitez | |
| Villager | Tsi Chin Li-McCall | |
| Restaurant Patron | Elgin Lee | |
| Guard | Rxchie | |
| Street Chase Pedestrian | David King | |
| Street Pedestrian | Megan Aldrich | |
| Businessman | Buddy Rahming | |
| Shop Worker | Yvette Miner | |
| Cable Car Rider | Kim Christopher Co.. | |
| Restaurant Patron | Timothy D. Montjoy | |
| NYC Subway passenger | Cerith Taylor | |
| Patient | A. Marshal Ward | |
| San Francisco Driver | Shawn Yee | |
| Cable Car Rider | Susanne B McGavin | |
| Dapper Dog Walker | 斯坦·李 |
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