| Sam Witwicky | 希亚·拉博夫
 | |
| Mikaela Banes | 梅根·福克斯
 | |
| Captain Lennox | 乔什·杜哈明
 | |
| USAF Tech Sergeant Epps | 泰瑞斯·吉布森
 | |
| Defense Secretary John Keller | 强·沃特
 | |
| Maggie Madsen | 瑞切尔·泰勒
 | |
| Agent Simmons | 约翰·特托罗
 | |
| Glen Whitmann | 安东尼·安德森
 | |
| USAF Staff Sergeant (as Josh Feinman) | 乔舒华·费恩曼
 | |
| Ratchet (voice) | 罗伯特·福克沃斯
 | |
| Bobby Bolivia | 伯尼·麦克
 | |
| FBI Agent | 杰米·麦克布莱德
 | |
| ACWO Jorge "Fig" Figueroa | 阿莫里·诺拉斯科
 | |
| Miles | 约翰·罗宾逊
 | |
| Megatron (voice) | 雨果·维文
 | |
| Tom Banacheck | Michael O'Neill | |
| Optimus Prime (voice) | 彼特·库伦
 | |
| Starscream (voice) | Charles Adler
 | |
| Little Girl | Sophie Bobal | |
| SOCCENT Op-Centre Tech | Charlie Bodin | |
| Cafe Kid | 安德鲁·卡德威尔
 | |
| SOCCENT Op-Centre Tech (as Lt. Frederic Doss) | Frederic Doss | |
| Ron Witwicky | 凯文·杜恩
 | |
| Admiral Brigham | 克里斯·埃里斯
 | |
| Analyst | Colin Fickes | |
| Mom in Car | Laurel Garner | |
| USMC Private (uncredited) | Sean Hampton | |
| Ironhide / Barricade (voice) | 杰斯·哈梅尔
 | |
| ASI Security Woman | Nicole Randall Johnson | |
| News Reporter | Jeremy Jojola | |
| Mahfouz | Ashkan Kashanchi | |
| Analyst | Thomas Lenk | |
| Akram | Rizwan Manji | |
| Witness | J.P. Manoux
 | |
| Jazz (voice) | Darius McCrary
 | |
| R&D Team Leader | Andy Milder | |
