| 角色 | 饰演者 | 角色介绍 |
| Jake Sully | 萨姆·沃辛顿  | |
| Neytiri | 佐伊·索尔达娜  | |
| Dr. Grace Augustine | 西格妮·韦弗  | |
| Norm Spellman (as Joel David Moore) | 乔·大卫·摩尔  | |
| Parker Selfridge | 吉奥瓦尼·瑞比西  | |
| Trudy Chacon | 米歇尔·罗德里格兹 | |
| Tsu'tey | 拉兹·阿隆索 | |
| Eytukan | 韦斯·斯塔迪 | |
| Moat | 希·庞德  | |
| Dr. Max Patel | 迪利普·劳 | |
| Corporal Lyle Wainfleet | Matt Gerald | |
| Private Fike | Sean Anthony Moran | |
| Cryo Vault Med Tech | Jason Whyte | |
| Venture Star Crew Chief | Scott Lawrence | |
| Lock Up Trooper | Kelly Kilgour | |
| Shuttle Pilot | J. Patrick Pitts | |
| Shuttle Co-Pilot | Sean Patrick Murphy | |
| Shuttle Crew Chief | Peter Dillon | |
| Tractor Operator | Kevin Dorman | |
| Dragon Gunship Pilot | Kelson Henderson | |
| Dragon Gunship Gunner | David Van Horn | |
| Dragon Gunship Navigator | Jacob Tomuri | |
| Suit #1 | Michael Blain-Rozgay | |
| Suit #2 | Jon Brent Curry | |
| Ambient Room Tech | Julene Renee | |
| Ambient Room Tech | Luke Hawker | |
| Ambient Room Tech | Woody Schultz | |
| Horse Clan Leader | 彼得·门萨 | |
| Link Room Tech | Sonia Yee | |
| Basketball Avatar | Ilram Choi | |
| Na'vi Child | Kyla Warren | |
| Troupe | Chris Mala | |
| Nav'i (uncredited) | Nicole Dionne | |
| Trooper (uncredited) | Jamie Harrison |
